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Briefly mentioned in the episode A Dream of an Oasis.  The Monsters in Wolf's Rain are apparently the cause that lead to the events of the tv series

HistoryEdit

Long ago when the world was young it came under threat by giant humanoid like monsters that nearly destroyed all life, but a place called Paradise opened up, and from its open doors wolves came forth.

After several climatic battles the wolves killed all the monsters, and thus allowed life to be reborn.